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Dietary advice based on food specific IgG Results

Forrás: Geoffrey Hardman, Gillian Hart, University of York, Heslington, York, UK. Nutrition and food science Vol 37 No 1 2007 pp 16-23

Purpose – Evidence has suggested that elimination diets based on food-specific IgG measurement can lead to improvements in chronic ill health symptoms. This paper aims to review the evidence from studies on food-specific IgG measurement and dietary change. Design/methodology/approach – A literature review of studies on the putative role for food-specific IgG-based elimination diets was undertaken. Findings – The use of fully standardised clinically evaluated food-specific IgG tests as a basis for elimination diet could lead to a considerable improvement in many patients" quality of life. Originality/value – This unique review captures evidence for a viable alternative to the time consuming and expensive elimination diet/food challenge approach.

IgG Antibodies against Food Antigens are Correlated with Inflammation and Intima Media Thickness in Obese Juveniles

Forrás: M. Wilders-Truschnig, H.Mangge, C.Lieners, H.J.Gruber, C Mayer, W Marz Exp Clin Endocrinol Diabetes 2008; 116:241-245

OBJECTIVE: Systemic low grade inflammation may contribute to the development of obesity, insulin resistance, diabetes mellitus and atherosclerotic vascular disease. Food intolerance reflected by immunoglobulin G (IgG) antibodies may predispose to low grade inflammation and atherogenesis. We examined the relationship between IgG antibodies specific for food components, low grade inflammation and early atherosclerotic lesions in obese and normal weight juveniles. RESEARCH METHODS AND PROCEDURES: We determined IgG antibodies directed against food antigens, C-reactive protein (CRP) and the thickness of the intima media layer (IMT) of the carotid arteries in 30 obese children and in 30 normal weight children. RESULTS: Obese juveniles showed a highly significant increase in IMT (p=0.0001), elevated CRP values (p=0.0001) and anti-food IgG antibody concentrations (p=0.0001) compared to normal weight juveniles. Anti-food IgG showed tight correlations with CRP (p=0.001/r=0.546) and IMT (p=0.0001/r=0.513) and sustained highly significant in a multiple regression model. DISCUSSION: We show here, that obese children have significantly higher IgG antibody values directed against food antigens than normal weight children. Anti- food IgG antibodies are tightly associated with low grade systemic inflammation and with the IMT of the common carotid arteries. These findings raise the possibility, that anti-food IgG is pathogenetically involved in the development of obesity and atherosclerosis.

Metabolic Syndrome-A Comprehensive Perspective Based on Interactions Between Obesity,Diabetes, and Inflammation

Forrás: Paresh Dandona, MD, PhD; Ahmad Aljada, PhD; Ajay Chaudhuri, MD; Priya Mohanty, MD; Rajesh Garg, MD Contemporary Reviews in Cardiovascular Medicine DOI: 10.1161/01.CIR.0000158483.13093.9D

The original description of the metabolic syndrome by Reaven1 consisted of obesity, insulin resistance, hypertension, impaired glucose tolerance or diabetes, hyperinsulinemia and dyslipidemia characterized by elevated triglyceride, and low HDL concentrations. All of the features described above are risk factors for atherosclerosis, and thus, metabolic syndrome constituted a significant risk for coronary heart disease2–5 (Table). The features of obesity/overweight and insulin resistance also provided a significant risk for developing type 2 diabetes.5,6 The risks for coronary heart disease and diabetes with metabolic syndrome are greater than those for simple obesity alone, and therefore, an understanding of the pathogenesis and through it, a rational approach to its therapy are of prime importance.

Is Obesity an Inflammatory disease?

Forrás: Presented at the 64th Annual Meeting of the Society of University Surgeons, Houston, Texas, February 12-15, 2003.Eduardo J.B. Ramos, MD, Yuan Xu, MD, Irina Romanova, PhD, Frank Middleton, PhD, Chung Chen, PhD, Robert Quinn, DVM, Akio Inui, MD, PhD, Undurti Das, MD, Michael M. Meguid, MD, PhD

Background. Most obese individuals have elevated concentrations of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), markers of inflammation closely associated with diabetes, hypertension, and stroke. Hypothesis. Obesity is a low-grade inflammatory disease, and Roux-en-Y gastric bypass (RYGB) reduces biochemical markers of inflammation and modifies gene expression in hypothalamic food intake/energy-related nuclei and subcutaneous abdominal fat (SAF). Methods. Obesity was induced in 24 3-week-old Sprague Dawley pups fed a high-energy diet (HED). Three groups (n = 8/group) were studied: RYGB, sham-operated pair-fed, and sham-operated ad libitum HED. Controls were nonobese rats fed chow (n = 6). Rats were killed 10 days after operation, and blood was collected to measure corticosterone and SAF and mesenteric fat to measure IL-6, TNF-α, and corticosterone. Total mRNA from arcuate nucleus and SAF purified for gene expression profiling. Data were analyzed with analysis of variance, Mann-Whitney test, and t test. Results. Before operation, the body weight of the obese groups was 493 ± 7 g and control = 394 ± 12g. The 10-day postoperative weight was RYGB = 417 ± 21 g, pair-fed = 436 ± 14 g, and ad libitum HED = 484 ± 15 g. Mesenteric and SAF weight decreased in RYGB. Mesenteric/SAF ratio of IL-6, TNF-α, corticosterone, and gene profiling showed decrease of inflammation after RYGB. Conclusion. Gastric bypass reduces biochemical markers of inflammation, suggesting that obesity is an inflammatory condition. (Surgery 2003;134:329-35.)

The effect of weight loss on C-reactive protein: a systematic review.

Forrás: Selvin E, Paynter NP, Erlinger TP, Arch Intern Med. 2007 Jan 8;167(1):31-9

Background: Several studies suggest that weight loss reducesC-reactive protein (CRP) level; however, the consistency and magnitude of this effect has not been well characterized. Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level. Data Sources: We searched the Cochrane Controlled Trials Register and MEDLINE databases and conducted hand searches and reviews of bibliographies to identify relevant weight loss intervention studies. Study Selection:We included all weight loss intervention studies that had at least 1 arm that was a surgical, lifestyle, dietary, and/or exercise  intervention. Abstracts were independently selected by 2 reviewers. Data Extraction: Two reviewers independently abstracted data on the characteristics of each study population, weight loss intervention, and change inweight and CRP level from each arm of all included studies. Data Synthesis:We analyzed themean change in CRP level (milligrams per liter) and the mean weight change (kilograms), comparing the preintervention and postintervention values from each arm of 33 included studies using graphical displays of these data and weighted regression analyses to quantify the association. Results: Weight loss was associated with a decline in CRP level. Across all studies (lifestyle and surgical interventions), we found that for each 1 kg of weight loss, themean change in CRP level was −0.13mg/L (weighted Pearson correlation, r=0.85). The weighted correlation for weight and change in CRP level in the lifestyle interventions alone was 0.30 (slope, 0.06). The association appeared roughly linear. Conclusion: Our results suggest that weight loss may be an effective nonpharmacologic strategy for lowering CRP level.

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